5-htp & Mdma

5-HTP is a precursor to 5-HT (serotonin). Since 5-HTP can boost the amount of serotonin in your brain, you can run the risk of developing serotonin syndrome when MDMA is taken in conjunction with 5-HTP.

Using 5-HTP before MDMA is fine, but it is wise to stop taking 5-HTP 24-48 hours before taking MDMA to minimize the risk of serotonin syndrome.

https://www.progressivehealth.com/5-htp-mdma.htm


https://psychonautwiki.org/wiki/5-Hydro … teractions

Dangerous interactions

Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Combinations in the list below may increase the amount of neurotransmitters, such as serotonin, to dangerous or even fatal levels, resulting in life-threatening serotonin syndrome.

    Selective serotonin re-uptake inhibitors (SSRIs) - When combined with antidepressants of the SSRI class, high doses of 5-HTP can cause acute serotonin syndrome in rats.[12][13]
    Serotonin-norepinephrine reuptake inhibitors (SNRIs)
    Serotonin releasers such as MDMA, 4-FA, MDAI and ?MT - To prevent serotonin syndrome, 5-HTP should only be taken once the user has come down from the MDMA (or other serotonin releaser), roughly 12 hours after the last dose.
    MAOIs such as syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, ?MT, and some antidepressants - When combined with antidepressants of the MAOI class, high doses of 5-HTP can cause acute serotonin syndrome in rats.[12][13]
    Tricyclic antidepressants (TCAs)
    Tramadol

https://pubmed.ncbi.nlm.nih.gov/17629409/

Le probleme avec le syndrome seroto est qu'il est mal connu, donc considéré comme  rare et imprevisible.
A mon avis un traitement au 5-HTP n'a pas besoin d'etre prolongé.

5-HTP is also popularly consumed by users of MDMA and other serotonin-releasing agents to try to reduce the negative after effects that begin during the substance's come down period, including anxiety, depression, and cognitive fatigue.[2] Since 5-HTP is a precursor for the neurotransmitter serotonin and MDMA administration both depletes serotonin levels in the brain as well as inhibit the enzyme needed to produce it (i.e. tryptophan hydroxylase) for a short period after,[3] it is believed that taking 5-HTP in the days after coming down will speed up the production of serotonin and decrease the time needed to recover (though there are many popular misconceptions and controversies as to just how effective it is for this purpose).[

Donc, dans ton cas, je mettrais plutot quelques jours entre l'arret du tt et une prise de MDMA.
Amicalement

Dernière modification par prescripteur (30 novembre 2020 à  09:37)