[ Interaction & Mélange ]

LSD et interactions medicamenteuse

Nalala a écrit

Je prends le trittico (neuroleptique)

Bonjour,

T'es sur que c est un neuro ce médicament ? Ça a l'air d'être un composé un peu étrange ce truc? Pas un benzo, pas un neuro, pas un isrs...

Du coup je ne saurais que trop te conseiller d'être vraiment précautionneuse.

Prend soin de toi et ne te précipite pas, attend de voir si quelqu'un connaît un peu cette molécule...

Ocram

Nalala a écrit

En tout cas merci pour ta réponse. Je serai prudente (abstinente) en attendant d’en savoir plus, mais faudrait presque un chimiste ou un pharmacologue pour répondre ?

En tout cas dans l'équipe de PA il y a prescripteur qui est medecin il pourra probablement nous aidé. Il y a également Suf qui bosse dans le médical...

Je vais faire suivre...

Ocram

Summary

If you don't feel like reading this whole thing, here are the essential points you need to know:

1. There is still very little legitimate, thorough medical research on this subject. LSD's outlaw status makes it very difficult to obtain permission & funding for research. Therefore, you should regard all of the anecdotes and conclusions here as being scientifically unproven, and you should note that any experimentation you choose to do carries a significant risk.

2. Lithium or tricyclics (like Amitriptyline, Anafranil, Asendin, Aventyl, Elavil, Endep, Norfranil, Norpramin, Pamelor, Sinequan, Surmontil, Tipramine, Tofranil, Vivactil) are fairly consistently reported as being very bad in combination with LSD. People attempting this combination are unable to communicate with others, they go into "fugue states" where they end up in other places and don't know how they got there, and they are generally in a terrible place psychologically. Life-threatening seizures and at least one DEATH have been reported to be triggered by the combination of LSD and lithium.

3. SSRIs (like Prozac, Paxil, Zoloft, Celexa, Desyrel) or MAOIs (like Nardil, Parnate, Marplan, Eldepryl, Aurorix, Manerix) are fairly consistently reported to noticeably reduce the effects of LSD. MAOIs seem to cause a greater reduction in the effects of LSD than SSRIs.

Article Title: On the central antiserotonin action of trazodone.

Article Source: Pol J Pharmacol Pharm 1979 Jan-Feb;31(1):25-33

Author(s): Baran L; Maj J; Rogoz Z; Skuza G

Abstract: Trazodone, an antidepressant drug with an unknown mechanism of action, has been examined in order to demonstrate its central antiserotonin action. Trazodone antagonizes the head twitch response induced by 5-hydroxytryptophan in rats and mice, or by-5-methoxytryptamine in rats (the ED50 values are 9.3, 5.2, and 10.8 mg/kg respectively). It counteracts convulsions induced by tryptamine in rats (ED50=3.75 mg/kg). Trazodone abolishes hyperthermia induced by serotoninomimetics (LSD, quipazine, fenfluramine) in rabbits. It does not affect ptosis induced by reserpine, and diminishes stimulation of the locomotor activity induced by amphetamine. Our findings demonstrate that trazodone has a central antiserotonin action, similarly as three other antidepressant drugs: mianserin, danitracen and doxepin, whose central antiserotonin action has been found previously.

Amicalement

Dernière modification par prescripteur (22 août 2019 à  18:00)