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"This wasn't just reduced brain activity. After the high dose of ketamine the brains of these sheep completely stopped. We've never seen that before," says neurobiologist Jenny Morton from the University of Cambridge.
"A few minutes later their brains were functioning normally again – it was as though they had just been switched off and on."
https://www.sciencealert.com/ketamine-e … before/amp
Voilà de quoi spéculer sur les effets de la Ketamine et sur son mode d'action.
NDE ? K-hole ? Cette sensation de reset a déjà été décrite par des ketausaures.
Effectivement, il y a matière penser que cette forme de mort cérébrale temporaire n'y est pas étrangère.
At the highest intravenous dose used (24 mg/kg), in 5/6 sheep we observed a novel effect of ketamine, namely the complete cessation of cortical EEG activity. This persisted for up to several minutes, after which cortical activity resumed. This phenomenon is likely to explain the ‘k-hole’, a state of oblivion likened to a near death experience that is keenly sought by ketamine abusers.
3 étapes identifiées :
Characteristic dose-dependent behavioural and quantitative EEG responses of sheep to ketamine
The behavioural response of sheep to ketamine can be separated into three distinct sequential phases based on the behaviour and the electromyogram (EMG)/electroocculogram (EOG) activity (Fig. 1). The first phase, seen shortly after delivery of ketamine, is characteristic of the well-described anaesthetic effect21. During this phase, voluntary movement is suppressed, as are eye movements, although the eyes remain open and they have intact palpebral (eye blink) reflexes. In this phase there is typically increased muscle tone22, which was evident in the EMG trace (see below). In the second phase, sheep are conscious and respond to gentle sensory stimulation such as incidental noise or movements in the visual field, but do not engage in voluntary movement. This corresponds to the dissociative analgesic phase. During the third phase, sheep are conscious and appear alert, with awake levels of EMG and EOG activity, although again they do not engage in voluntary movement. The duration of each of these phases is dose-dependent (data not shown).
https://www.nature.com/articles/s41598-020-66023-8
Dernière modification par Mister No (17 juin 2020 à 18:35)
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Dernière modification par Rick (18 juin 2020 à 07:13)
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