[ Etude ]

la décarbo

Wang Mei, et al.
Étude de la décarboxylation des cannabinoïdes acides: une approche novatrice utilisant la chromatographie liquide à ultra-haute performance et la spectrométrie de masse à photodiodes. Cannabis and Cannabinoid Research. 2016, 1(1): 262-271. Les auteurs ont constaté qu'à des températures inférieures à 100°C, la décarboxylation du THCA n'atteignait pas son terme en 60 minutes. À des températures plus élevées, le THCA a été complètement décarboxylé après 30, 9 et 6 min à 110°C, 130°C et 145°C, respectivement.

https://www.liebertpub.com/doi/full/10. … .2016.0020

?9-Tetrahydrocannabinolic acid A

Figure 3 shows the results of the decarboxylation reactions for THCA-A??9-THC. At temperatures lower than 100°C, the reaction did not reach completion within 60 min. At higher temperatures, the concentration of THCA-A approached zero in 30, 9, and 6 min at 110°C, 130°C, and 145°C, respectively. The stoichiometry of the reaction is shown in Figure 4, where the concentrations of ?9-THC and THCA-A and their sum are plotted as a function of time. The results indicate complete conversion of THCA-A??9-THC. The sum of the molar concentration of THCA-A and ?9-THC decreased slightly after the decarboxylation, the relative loss is given in Table 1. Figure 4 also shows the data for CBN, which is a possible oxidation product of ?9-THC. In this case, heating in the dark and in the absence of oxygen (vacuum oven) did not result in any significant oxidation of ?9-THC to CBN. Finally, decarboxylation studies with pure THCA-A showed clearly that ?9-THC was the only decomposition product observed after heating at 110°C for 40 min.

Dernière modification par Mister No (05 mars 2019 à  13:23)