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Elimination [label=/sujet/methadone a écrit
Methadone[/label]]Excretion
The elimination of methadone is mediated by extensive biotransformation, followed by renal and fecal excretion.
Published reports indicate that after multiple dose administration the terminal half-life (T 1/2 ) was highly variable and ranged between 8 to 59 hours in different studies.
Since methadone is lipophilic, it has been known to persist in the
liver and other tissues. The slow release from the liver and other tissues may prolong the duration of methadone
action despite low plasma concentrations.
Source: Columbus, Ohio: Roxane; 2006. Methadone HCl tablets USP (Dolophine HCl CII), prescribing information. Disponible à l'url : www.accessdata.fda.gov/drugsatfda_docs/ … 28lbl.pdf. Accessed July 5, 2011.
half-life-methadone.pdf
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