La demi vie de l'olanzapine est d'environ 36 heures. Donc pour avoir une baisse significative il faut au moins 2 demi vies soit 3 jours.
https://fr.wikipedia.org/wiki/OlanzapineL'interaction est modérée et constitue surtout une accentuation des effets secondaires tels que vertiges, somnolence, confusion et difficultés à se concentrer. Mais c'est valable pour des doses "thérapeutiques".
Pour des doses supra-thérapeutiques je n'ai pas de renseignement.
Amicalement
https://www.drugs.com/drug-interactions … 744-0.htmlInteractions between your drugs
Moderate
dextromethorphan OLANZapine
Applies to: dextromethorphan and olanzapine
Using dextromethorphan together with OLANZapine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.