le paracetamol améliore certaines anxiétés

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prescripteur homme
Modérateur
Inscrit le 22 Feb 2008
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Selon une étude récente le paracetamol diminue l'anxiété liée au deuil et aux événements analogues au deuil (angoisse existentielle). Ci joint une copie (en anglais ctuellement seulement) d'un article + une référence à  un article plus ancien. Amicalement.


PRESS RELEASE
April 16, 2013
For Immediate Release
Contact: Anna Mikulak
Association for Psychological Science
202.293.9300
amikulak@psychologicalscience.org
Experiencing Existential Dread? Tylenol May Do the Trick
Related Topics: Anxiety, Attitude, Brain, Interventions, Psychological Science, Thinking, Threat

Thinking about death can cause us to feel a sort of existential angst that isn’t attributable to a specific source. Now, new research suggests that acetaminophen, an over-the-counter pain medication, may help to reduce this existential pain.

The research is published in Psychological Science, a journal of the Association for Psychological Science.

According to lead researcher Daniel Randles and colleagues at the University of British Columbia in Canada, the new findings suggest that Tylenol may have more profound psychological effects than previously thought:

“Pain extends beyond tissue damage and hurt feelings, and includes the distress and existential angst we feel when we’re uncertain or have just experienced something surreal. Regardless of the kind of pain, taking Tylenol seems to inhibit the brain signal that says something is wrong.”

Randles and colleagues knew from previous research that when the richness, order, and meaning in life is threatened ”” with thoughts of death, for instance ”” people tend to reassert their basic values as a coping mechanism.

The researchers also knew that both physical and social pain ”” like bumping your head or being ostracized from friends ”” can be alleviated with acetaminophen. Randles and colleagues speculated that the existentialist suffering we face with thoughts of death might involve similar brain processes. If so, they asked, would it be possible to reduce that suffering with a simple pain medicine?

The researchers had participants take either Tylenol brand acetaminophen or a sugar pill placebo in a double-blind study. One group of participants was asked to write about what would happen to their body after they die, and the control group was asked to write about having dental pain, an unpleasant but not existentially distressing thought.

All the participants were then asked to read an arrest report about a prostitute, and to set the amount for bail.

Just as expected, the control group that wrote about dental pain ”” who weren’t made to feel an existentialist threat ”” gave relatively low bail amounts, only about $300. They didn’t feel the need to assert their values.

On the other hand, the participants who wrote about their own death and were given a sugar pill gave over $400 for bail, in line with previous studies. They responded to the threat on life’s meaning and order by affirming their basic values, perhaps as a coping mechanism.

But, the participants in this group who took Tylenol were not nearly as harsh in setting bail. These results suggest that their existential suffering was ‘treated’ by the headache drug.

A second study confirmed these results using video clips. People who watched a surreal video by director David Lynch and took the sugar pill judged a group of rioters following a hockey game most harshly, while those who watched the video and took Tylenol were more lenient.

The study demonstrates that existentialist dread is not limited to thinking about death, but might generalize to any scenario that is confusing or surprising ”” such as an unsettling movie.

“We’re still taken aback that we’ve found that a drug used primarily to alleviate headaches can also make people numb to the worry of thinking about their deaths, or to the uneasiness of watching a surrealist film,” says Randles.

The researchers believe that these studies may have implications for clinical interventions down the road.

“For people who suffer from chronic anxiety, or are overly sensitive to uncertainty, this work may shed some light on what is happening and how their symptoms could be reduced,” Randles concludes.

###

In addition to Randles, co-authors on this research include Steven Heine and Nathan Santos of the University of British Columbia.

This research was supported by a grant and doctoral fellowship from the Social Sciences and Humanities Research Council.

For more information about this study, please contact: Daniel Randles at danielrandles@psych.ubc.ca and Steven Heine at heine@psych.ubc.ca.
###

The APS journal Psychological Science is the highest ranked empirical journal in psychology. For a copy of the article "The Common Pain of Surrealism and Death: Acetaminophen Reduces Compensatory Affirmation Following Meaning Threats" and access to other Psychological Science research findings, please contact Anna Mikulak at 202-293-9300 or amikulak@psychologicalscience.org.

voir aussi
http://www.psychologicalscience.org/ind … lenol.html

S'il n'y a pas de solution, il n'y a pas de problème. Devise Shadok (et stoicienne)

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Alain Will homme
ancien Vice-Président
Inscrit le 14 Oct 2008
9618 messages
Eh ben, avec la quantité de paracétamol, de diazepam et de codéine que je prends tous les jours, punaise... Je dois avoir une tolérance astronomique pour toujours ressentir des crises d'angoisse telles que je les ressent... Ou alors le type de mes crises d'anxiété est "hors-normes" ! roll

Merci en tout cas pour l'article prescripteur merci-1

Amicalement, Alain W.

Il m'arrive de trouver que la vie est une horrible plaisanterie. F. Sagan.

Je vois dans la révolution la revanche du faible sur le fort. La liberté est un mot que j'ai longtemps chéri. Sade (Le marquis de)

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Mad Professor
Tableau B
Inscrit le 19 Apr 2010
832 messages
Avant le paracétamol il y avait la phénacétine, précurseur du paracétamol.

Elle a été retirée du marché, mais elle provoquait souvent des états d'euphorie et de bien être... Du coup, cela ne m'étonne pas du tout que le paracétamol puisse être un peu anxiolytique (ça ne vaudra jamais une benzo, mais comme on réagit tous différemment aux produits...).

La marge, c'est ce qui tient la page (Jean-Luc Godard)

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Kevin homme
Psycho junior
Inscrit le 15 Apr 2012
472 messages
Le cas du paracétamol est intéressant. C'est aujourd'hui un des médicaments les plus consommés à  travers le monde alors que son mécanisme d'action est encore relativement incertain.
J'ai été assez amusé d'apprendre que le paracétamol agissait sur le système cannabinoïde endogène, en inhibant la recapture d'anandamide. Ce n'est pas son mécanisme d'action principal mais je trouve ça intéressant à  souligner.

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