L'etude est en effet citée par beaucoup de journaux. J'ai cherché l'article initial. Le résumé (que je copie à la suite. Evidemment il est en anglais) est gratuit, pas l'article. Je pense que l'
alcool au moins et peutvetre le
tabac donneraient les mêmes résultats. Mais l'étude demandant plusieurs dizaines d'années n'est pas prêt d'être refaite ! Amicalement
PNAS
Proceedings of the National Academy of Sciences of the United States of America
Persistent
cannabis users show neuropsychological decline from childhood to midlife
1. Madeline H. Meiera,b,1,
2. Avshalom Caspia,b,c,d,e,
3. Antony Amblere,f,
4. HonaLee Harringtonb,c,d,
5. Renate Houtsb,c,d,
6. Richard S. E. Keefed,
7. Kay McDonaldf,
8. Aimee Wardf,
9. Richie Poultonf, and
10. Terrie E. Moffitta,b,c,d,e
+ Author Affiliations
1. aDuke Transdisciplinary Prevention Research Center, Center for Child and Family Policy,
2. bDepartment of Psychology and Neuroscience, and
3. cInstitute for Genome Sciences and Policy, Duke University, Durham, NC 27708;
4. dDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710;
5. eSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King´s College London, London SE5 8AF, United Kingdom; and
6. fDunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, School of Medicine, University of Otago, Dunedin 9054, New Zealand
1. Edited by Michael I. Posner, University of Oregon, Eugene, OR, and approved July 30, 2012 (received for review April 23, 2012)
AbstractRecent reports show that fewer adolescents believe that regular
cannabis use is harmful to health. Concomitantly, adolescents are initiating
cannabis use at younger ages, and more adolescents are using
cannabis on a daily basis. The purpose of the present study was to test the association between persistent
cannabis use and neuropsychological decline and determine whether decline is concentrated among adolescent-onset
cannabis users. Participants were members of the Dunedin Study, a prospective study of a birth cohort of 1,037 individuals followed from birth (1972/1973) to age 38 y.
Cannabis use was ascertained in interviews at ages 18, 21, 26, 32, and 38 y. Neuropsychological testing was conducted at age 13 y, before initiation of
cannabis use, and again at age 38 y, after a pattern of persistent
cannabis use had developed. Persistent
cannabis use was associated with neuropsychological decline broadly across domains of functioning, even after controlling for years of education. Informants also reported noticing more cognitive problems for persistent
cannabis users. Impairment was concentrated among adolescent-onset
cannabis users, with more persistent use associated with greater decline. Further, cessation of
cannabis use did not fully restore neuropsychological functioning among adolescent-onset
cannabis users. Findings are suggestive of a neurotoxic effect of
cannabis on the adolescent brain and highlight the importance of prevention and policy efforts targeting adolescents.
marijuana longitudinal
cognition
Footnotes
↵1To whom correspondence should be addressed. E-mail: madeline.meier@duke.edu.
Author contributions: M.H.M., A.C., and T.E.M. designed research; M.H.M., A.C., A.A., H.H., R.H., R.S.E.K., K.M., A.W., R.P., and T.E.M. performed research; M.H.M., A.C., R.H., and T.E.M. analyzed data; and M.H.M., A.C., and T.E.M. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.