Toxicité du nitrazépam

Bonjour,

Voici ce que je lit dans Wikipédia en Anglais à  propos du nitrazépam et de ses dérivés clonazépam, nimétazépam et flunitrazépam :

Nitrobenzodiazepines such as nitrazepam, nimetazepam, flunitrazepam, and clonazepam are more toxic to the liver than other benzodiazepines as they are metabolically activated by CYP3A4 which can result in cytotoxicity. This activation can lead to the generation of free radicals and oxidation of thiol, as well as covalent binding with endogenous macromolecules; this results, then, in oxidation of cellular components or inhibition of normal cellular function. Metabolism of a nontoxic drug to reactive metabolites has been causally connected with a variety of adverse reactions..

J'avais pourtant appris que les benzodiazépines étaient toutes très peu toxiques et n'endommageaient pas les organes.

En savez-vous davantage ?

Merci.