[ Etude ]

Etude scientifique : les effets des microdoses du LSD en double aveugle.

extrait resume pubmed a écrit

Abstract
RATIONALE:

Previous research demonstrating that lysergic acid diethylamide (LSD) produces alterations in time perception has implications for its impact on conscious states and a range of psychological functions that necessitate precise interval timing. However, interpretation of this research is hindered by methodological limitations and an inability to dissociate direct neurochemical effects on interval timing from indirect effects attributable to altered states of consciousness.


METHODS:

We conducted a randomised, double-blind, placebo-controlled study contrasting oral administration of placebo with three microdoses of LSD (5, 10, and 20 µg) in older adults. Subjective drug effects were regularly recorded and interval timing was assessed using a temporal reproduction task spanning subsecond and suprasecond intervals.


RESULTS:

LSD conditions were not associated with any robust changes in self-report indices of perception, mentation, or concentration. LSD reliably produced over-reproduction of temporal intervals of 2000 ms and longer with these effects most pronounced in the 10 µg dose condition. Hierarchical regression analyses indicated that LSD-mediated over-reproduction was independent of marginal differences in self-reported drug effects across conditions.


CONCLUSIONS:

These results suggest that microdose LSD produces temporal dilation of suprasecond intervals in the absence of subjective alterations of consciousness.

Une étude menée en double aveugle avec des microdoses de 5 , 10 et 20 microgrammes (mcg ou µg) et placébo utilisés de manière aléatoire sur 48 personnes (46%f 54%m) agé entre 55 - 75 ans.

"On each dosing day, participants completed a battery ofcognitive and perceptual tasks (...) Participants completedthe task whilst sitting in their beds using a 17-in. laptop(Lenovo; G770) that was positioned on an overbed table at adistance of approximately 60 cm. Stimulus presentation was implemented using Psytools 1.39 (Psytools, Delosis, London, UK). Instructions were provided on-screen and by experi-menters. Participants completed one practice block of nine randomised trials and four experimental blocks of 27 randomised trials, amounting to 108 trials (12 per interval).
The task took approximately 15–20 min to complete."

les auteurs pensent qu'il n'y a pas de résultats significatifs :

"These results suggest that
the task was completed at a relatively uniform post-dose time
across conditions."

(...)

"Cumulatively, these results suggest thatmicrodose LSD did not produce robust changes in a range of conscious states, as indexed by self-report measures."

toutefois il en ressort qu'il y aurait peut être une petite dilatation du temps ressenti
enfin bon je ne veux pas trop vous influencer j'ai souhaité faire un petit résumé pour ceux qui ne pourront pas lire le document en anglais. Pour les autres , aucune excuse : c'est passionnant . Enfin une étude sérieuse sur un "stupéfiant" et sur le sujet très "hype" du microdosing. Merci pour votre lecture.

Dernière modification par pierre (08 décembre 2018 à  22:59)