Le dangereux leurre du Kratom

Dernière modification par Rick (26 octobre 2018 à  12:14)

Mitragynine shows negligible toxicity, even at high doses. For example, no fatalities were recorded in rats given 1000 mg/kg oral doses of kratom leaf extract or 806 mg/kg isolated mitragynine. Rhesus monkeys injected with 9.2 mg/kg mitragynine (IV) also presented no fatalities.

But this doesn’t mean kratom is totally safe. For one thing, different preparations may contain different amounts of phytochemicals and adulterants. There’s also been relatively little research into the long-term health risks of regular kratom use.

Of particular concern are reports of seizures, which increased fivefold in Thailand between 2005 and 2011. Most kratom-related seizures are attributed to adverse drug combinations, but they’re still a cause for concern.

Liver problems may also occur after two to eight weeks of regular kratom use. Symptoms include nausea, itching, dark urine, abdominal pain, and jaundice. Heavy users might notice a hyperpigmentation or darkening of the cheeks due to over-stimulation of melanocytes. Kratom might also be cardiotoxic; further research is called for.

Some other issues linked to kratom use, albeit more rarely, include sleep problems, hypotension, tremors, temporary erectile dysfunction, sweating, hair loss, dry mouth, and anorexia.

Evidence suggests psychosis, including paranoid delusions, hallucinations, and confusion, may be caused by regular use spanning a decade or more. Animal studies have also highlighted a link between chronic use and memory/learning problems.

While a number of human fatalities have been linked to kratom use, there are usually other substances present. In one case, 0.6 mg/L mitragynine was detected alongside over-the-counter cold medicines and benzodiazepines.

Source : https://thethirdwave.co/psychedelics/kratom/

Donc le mieux avec le kratom, c'est de ne pas en prendre de manière chronique. Quitte à se soigner avec un opiacé/opioïde, autant le faire avec un médicament pharmaceutique. Je consomme et aime le kratom, mais la RDR me dit qu'il faut faire gaffe avec la qualité et en prendre que de manière occasionnelle, et surtout pas à visée thérapeutique. Et un jour, arrêter (demain).

Dernière modification par Funkanoïde (26 octobre 2018 à  16:25)

no fatalities

oui, mais ça met KO!

Rick a écrit

Mais comment prendre au sérieux un article qui parle d'hallucinations dans les effets décrits du kratom. Ou alors ai je manqué un épisode? merci pour la pépite psychic!

L'article de Floriane Thiébaut est très elliptique, pour aller plus loin je te conseille d'aller voir l'article de "TheThirdWave", que j'ai mis en lien plus haut (et que je replace ici https://thethirdwave.co/psychedelics/kratom/ ), il est plus complet et plus précis. Les hallucinations et autres troubles psychiques, assez graves (psychose), n'y sont pas présentés comme les signes de la défonce au kratom, mais comme des effets à long terme "causés par une utilisation régulière sur une décennie ou plus". Et là, au contraire de l'article de Floriane Thiébaut, ces dires sont sourcés. Les reports de troubles psychiques à long terme sont basés sur "A Study of Kratom Eaters in Thailand" : https://www.unodc.org/unodc/en/data-and … ge003.html

Où l'on voit qu'il n'y a que cinq cas répertoriés, dont deux prenaient aussi de l'alcool, de l'héroïne et des amphétamines :

There were five cases of kratom addiction revealing psychotic symptoms; these had been seen by the author in the last year (1974) in the outpatient department. Initially three cases were suspected of having kratom psychosis on the basis of their history of addiction and their general appearance and on psychiatric examination.

Case 1: A 55-year old Thai subject had begun eating kratom at the age of 20. His complaints were convulsions and mental confusion over the past few weeks. He was thin, his skin had become dark, particularly in the face on both cheeks, and it had an appearance similar to a hepatic face. Clouding of consciousness, experiencing of delusions and hallucinations were clearly evident.

Case 2: This 32-year old Thai was a labourer. He had begun using the kratom leaf daily at the age of 22 and had combined his kratom addiction with alcohol consumption for the past two years. He was confused and experienced persecutory ideation. He was admitted for two weeks; the result of the treatment was satisfactory.

Case 3: This 31-year old Thai was a married labourer who had begun eating kratom when he was 14. He complained of dizziness and headaches. He experienced hallucinations, delusion and confusion.
Only case 2 was admitted to the hospital, where major tranquillizers and supportive treatment were given. Cases 1 and 3 were out-patients, treated with major tranquillizers.

Cases 4 and 5 were psychotic patients. They had been multiple addicts, combining the use of kratom with alcohol, amphetamines and heroin. There were two cases of schizophrenia who had a history of kratom addiction and who were still users. While they were limited in social activity, they were good workers. None of them has relapsed during the past 10 years.

Si ça peut rassurer ...

Dernière modification par Funkanoïde (26 octobre 2018 à  22:47)