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Dernière modification par Sunshine Maker (18 janvier 2020 à 15:48)
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Deep_Artefakt a écrit
. Premier conseil du médecin : interdiction de fumer du tabac (soit, je ne fume pas beaucoup de toute manière) pour favoriser la cicatrisation et limiter le risque infectieux.
Bon c'est justement ce que j'allais te préciser.
Donc si conso que canna privilégier des alternatives sans combustion (huile en oral ou space bouffe, vaporisation, ce genre de trucs...).
Après si tu es un gros fumeur de clopes, mm avec un patch c dur de TT stop.
Si tu l'autorise qques clopes quotidiennes qd mm, mets les dans un joint de weed , ça vaut mieux...
Bon rétablissement!
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Cannabis use and risk of Clostridioides difficile infection: Analysis of 59,824 hospitalizations.
Adejumo AC1, Bukong TN2.
Author information
Abstract
BACKGROUND:
The prevalence of Clostridioides difficile Infection (CDI), the most notorious hospital acquired disease, and of excessive cannabis use (cannabis use disorder (CUD)) have both been steadily rising. Although cannabidiol, an active ingredient of cannabis, maintains gut integrity and suppresses entero-toxins from Clostridioides difficile, the relationship between CUD and CDI has not been studied.
METHODS:
We selected adult records (age?18 years) from the Nationwide Inpatient Sample 2014, and identified CUD and other clinical conditions using ICD-9-CM codes. We used propensity scores derived from a multivariate logistic model to match CUD to non-CUD in a 1:1 ratio (29,912:29,912). We estimated the relative risk for CDI using log-binomial regression models with generalized estimating equations [SAS 9.4].
RESULTS:
Among the matched hospitalizations (n=59,824), cannabis usage was associated with a reduced prevalence of CDI (prevalence: 455.5 [95% CI: 385.1-538.8] vs. 636.4 [95% CI: 549.9-736.5] per 100,000 hospitalizations), resulting in a 28% reduced risk of CDI (relative risk: 0.72 [95% CI: 0.58-0.88]; p=0002). Non-dependent and dependent CUD respectively had 23% and 80% reduced likelihood of CDI when compared to non-cannabis users (0.77 [95% CI: 0.60-0.95] and 0.20 [95% CI: 0.06-0.54]; p<0.05). Furthermore, dependent users had less risk of CDI compared to non-dependent users (0.26 [95% CI: 0.08-0.88]; p=0.01).
CONCLUSIONS:
CUD was associated with a decreased risk of CDI amongst hospitalized patients. Prospective and molecular mechanistic studies are required to elucidate how cannabis and its contents impacts CDI.
Copyright © 2019 Elsevier Ltd. All rights reserved.
KEYWORDS:
Cannabis; Clostridioides difficile infection; Diarrhea; Nosocomial infection; Risk factors
PMID: 31493498 DOI: 10.1016/j.anaerobe.2019.102095
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