tolérance entre mirtzapine et mercalm (dph)

prescripteur a écrit

Il est signalé uniquement une augmentation de la somnolence.

https://www.rxlist.com/drug-interaction … action.htm

Toutefois le wikipedia (en anglais) parle d'une desensibilisation des recepteurs H1 en cas de traitement continu. Est ce une explication ? Je ne sais pass.

https://en.wikipedia.org/wiki/Mirtazapine

H1 receptor
Mirtazapine is a very strong H1 receptor inverse agonist and, as a result, it can cause powerful sedative and hypnotic effects.[8] A single 15 mg dose of mirtazapine to healthy volunteers has been found to result in over 80% occupancy of the H1 receptor and to induce intense sleepiness.[81] After a short period of chronic treatment, however, the H1 receptor tends to desensitize and the antihistamine effects become more tolerable. Many patients may also dose at night to avoid the effects, and this appears to be an effective strategy for combating them. Blockade of the H1 receptor may improve pre-existing allergies, pruritus, nausea, and insomnia in afflicted individuals. It may also contribute to weight gain, however. In contrast to the H1 receptor, mirtazapine has only low affinity for the muscarinic acetylcholine receptors, although anticholinergic side effects like dry mouth, constipation, and mydriasis are still sometimes seen in clinical practice.[10

Amicalement

Merci beaucoup pour ces liens utiles !

Bien cordialement,