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SR-17018 pour descendre la tolerance.

leoxy a écrit

Bonjour a tous!

Je m 'intéresse a cette molécule qui selon les premières études aurait la capacité de diminuer la tolérance a la morphine tout en réduisant voir faisant disparaître les symptôme de manque.
Bon en tant que bon collectionneur de molécule divers et varié , une commande est déjà en chemin.
Mais je me pose quelques question: peut être que quelqu un peu m'aider à y répondre.....

SR-17018  étant similaire a la bupre ( cette histoire vieille histoire agonists antagonist), est on en rsique de symptôme de sevrage précipité en cas de prise trop proche?

Et bien sûr, l'un d'en vous à t'il déjà eu l'occase de l'experimentzr dans le but de se sevrer?
Parce que la comme ça, ça sonne un peu comme potentiellement la molécule de rêve de tout usager voulant stoper ou simplement descendre en tolérance.
Alors moi je veux bien une super molécule pour nous autre opiolovers mais ça sonne trop beau pour être vrai!

Je ne connais pas, mais je suis plus que intéressé par cette molécule.

Donc si tu peux nous tenir au courant de ta commande et expériences autour de sr 17018 ça sera fort appréciée.

Surtout la ''baisse de tolerance'' m’intrigué...

Cordialement

SR-17018 and Methadone - my experience (ongoing)

Hello everyone, I never usually post on here, but I want to make more information available for others who are considering trying SR-17018. I am trying to get myself off methadone with this chem. I will include my story/tolerance background, my dosing protocol, and will keep this thread updated as I continue my regimen.

Background: I have a fent tolerance and have dabbled in zenes ranging from weak to stupid strong (including meto, eto, proto, ndp, cychlorphine). I am currently stable on 100mg methadone per day.

Dosing: I haven’t messed around too much with the dosing yet, but I tried skipping singular days of methadone, 50mg 2x a day was enough to keep me from being sick. SR is supposedly around the potency of morphine when taken orally (in rats), so I assume it held me just because of the super long half life of methadone. As my experience progresses, I’ll fine tune the dose. Dosing only once a day with this chem will have you feeling sick as the half life seems to be around 8-12 hours.

Updates/Timeline and Results:

9/6/2024 - Last dose of 100mg methadone

9/8/2024 - Been 2 days no methadone, dosing SR 50mg 2x daily. Mild withdrawal symptoms (chills, stomach cramps). Might titrate the dose up in the following days.

9/10/2024 - Started taking 75mg as withdrawal symptoms were worsening. I know I’m not taking anywhere near the MME for my methadone dose. So not surprised I don’t feel too great.

9/12/2024 - 100mg twice a day seems to be pretty good. Today was the first day I haven’t felt sick at all. Think I’ll stay at this dose for a bit and then see how lowering it goes.

9/14/2024 - Still going strong! Not sick at all.

9/18/2024 - Been on 100mg twice a day for about a week now. Seems to be working out nicely. I know this seems like a high dose compared to what others say they are taking; but this is what is working for me. I’m sure my stuff isn’t 100% pure as well. I tried taking 3 shots of kratom last night to assess tolerance. I swear I could notice a little something. My tolerance is definitely still high, but definitely lower. The same dose of SR also feels a bit stronger. Will start trying to taper my dose down and see if I get sick. Can’t wait to be off opioids.

Edit 2: Honestly it’s insane that this stuff is able to keep me well jumping off a 100mg dose of methadone. Going cold turkey off methadone is usually terrible. Very grateful for this chem.

9/21/2024 - Have started to taper down over the past few days, sitting at 75mg twice a day now. Have not been noticeably sick. I do feel kind of crappy mentally, but I strongly believe the cold weather over the past few days has been fucking with me (I have diagnosed seasonal affective disorder). I’m going to continue my taper down, if I start feeling terrible mentally I will consider taking SR for maintenance. Theoretically I think the tolerance reducing effects of SR will make it so the taper wouldn’t make me sick at all (as long as I don’t jump down too quick), but I guess we’ll find out.

9/22/2024 - Down to 70mg per dose, reducing by 5mg/day. This might be too aggressive, guess I’ll find out. Also, just did a 12 panel drug test and I’m no longer popping for methadone!

9/24/2024 - Jumped down to 65, then 50 next dose, 45, and most recently (today at night) only 25mg. I know this is a rapid dose deescalation but haven’t been feeling sick at all and I’m eager to be done. I will probably stay at 25mg 2x daily for a couple more days before continuing to drop. I am running a bit low on SR and want to avoid buying more. Just want to give it a bit more time for the SR to do its thing.

9/25/2024 - I just took a 7oh kratom shot (the bottle claims 3 “doses”) and I swear I feel a little warm with a slight head high. It’s quite weak but it’s there, I definitely felt the onset. I never could’ve dreamed I’d be able to feel anything weaker than fent again. This chem is a fucking godsend. I will try some O-DSMT once I’m completely off SR (in a couple days).

9/26/2024 - I actually forgot to take my SR last night and I woke up with a bit of a messed up stomach (cramps), but not sick. I took 10mg this morning, I plan for this to be my last dose. It’s truly crazy I was able to come off 100mg methadone with this chem. Will update in the next few days when I see how I feel with no opioids at all.

9/27/2024 - Feeling fine. I just took some O-DSMT to test tolerance. Will update.

Edit: It reminded me of the first time I ever had O-DSMT. Warm fuzzy euphoria and opioid headspace. I had to take quite a bit but that’s probably because I still have some buprenorphine in my system from that horrible Sublocade injection (it’s literally been 6+ months and I’m still popping for bupe). I’m still blown away that I’m able to feel this at all.

9/28/2024 - Back to no opioids after a one day binge yesterday. As others have pointed out, I haven’t had a good stretch of no opioids because I tried kratom and O-DSMT. Will update in a few days if something unexpected happens, if I don’t, assume everything’s feeling fine. Glad to be done.

9/30/2024 - Still feeling fine. 72 hours no opioids. Cravings are definitely back without SR. I’ll copy what I said in a comment: It’s definitely due to my own fault, I know that. I’m still a junkie deep down. I am grateful that SR helped me get off methadone, I understand it is entirely my responsibility what I do from here.

10/9/2024 - Got reminded of this post because I saw someone else starting the same journey. Just wanted to say I have been opioid free for the first time since my addiction started.
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u/Background_Room_2689 avatar
Background_Room_2689
•
4mo ago

Please let us know if it appears to be changing your tolerance at all. The info on sr is little and very interesting. People talk about it lowering tolerance. When you readminister methadone please pay attention to any difference in effect. I would like to use SR to lower my tolerance to make my daily methadone more effective. Is this feasible with this compound or nah?
u/ExOblivione161 avatar
ExOblivione161
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4mo ago
• Edited 4mo ago

It won’t do this. I just ran that experiment for 7 days. Coadministering 50mg SR with 100mg methadone. Absolutely no effect to be noted. Edit: although the most likely way for it to affect tolerance would be forgoing the methadone for several days using SR. But at that rate it’s only the SR keeping you well while you have no full agonist in you. I planned on CTing off 100mg methadone using SR in a couple weeks, but I’ll be watching this thread to see how that goes
opiumphile
•
4mo ago

You were adding it to your daily methadone, that's not the case here.
u/ExOblivione161 avatar
ExOblivione161
•
4mo ago

I should add that my intention in that experiment was to see if SR was at all similar to DAMGO. When DAMGO is coadministered with an opioid in tolerant individuals for 7 days their tolerance returns to baseline levels. Considering that available research sometimes compares SR to DAMGO I was curious to see if the same effect might be seen. The answer was no, obviously
u/ExOblivione161 avatar
ExOblivione161
•
4mo ago

The other use case doesn’t strike me as being too dissimilar from simply skipping your methadone to lower tolerance. I’ve skipped two days of methadone both with and without SR and haven’t noticed any perceptible difference in effect between the two. Now, going longer is something I haven’t done yet, as that’s the point where the clinic is going to drop my dose. I intended to CT from 100mg in a couple weeks, exactly as OP is doing here. Now that someone else is doing this experiment for me, I may modify that plan, pending the results here. The question I’m interested in is the level of discomfort while the body readjusts
u/Difficult_One4749 avatar
Difficult_One4749
•
4mo ago

To answer your question on the adjustment period: It was relatively easy to transition, even though I was barely taking any SR at the beginning when I hopped off my methadone (I’m sure the long methadone half life helped me there). The discomfort was mild, I didn’t get the dreaded RLS or really anything much beyond chills and abdominal cramps.
CertainExtreme7928
•
3mo ago

THIS
u/Difficult_One4749 avatar
Difficult_One4749
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4mo ago
• Edited 4mo ago

I’m going to give it about a week and then try taking a small amount of methadone. I’ll let you know if it feels any different.

Edit: It did not yet
BlackGoatSemen
•
4mo ago

Thanks for your contribution to the cause

Dernière modification par prescripteur (07 janvier 2025 à  10:44)

Dernière modification par cependant (08 janvier 2025 à  20:21)