[ Effets ]

Antidépresseur et tramadol

Bonsoir,

Merci pour ta réponse.
La fluoxitine peut elle m'aider à diminuer le tramadol ?

La fluoxitine peut elle m'aider à diminuer le tramadol ?

Possible mais pas certain . Chacun reagit à sa maniere. Amicalement

Bonjour, le tapentadol est proche du Tramadol mais avec un effet opioide plus fort et serotoninergique plus faible. La puissance analgesique est discutée mais semble nettement plus forte (multipliée par 2 à 4 selon les sources) avec le Tapentadol. Donc je dirais que 100 mg de Tapentadol ne sont pas equivalents à 100 mg de Tramadol. Mais il faut voir s'il s'agit d'une forme retard pour l'equivalence sur la journée.  Amicalement.



https://base-donnees-publique.medicamen … ;typedoc=N

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318929/

We conducted a narrative review of the literature to compare the pharmacological, efficacy and safety profiles of tapentadol and tramadol, and to assess the clinical interest of tapentadol in adult patients. Tapentadol and tramadol share a mixed mechanism of action, including both mu-agonist and monoaminergic properties. Tapentadol is approximately two to three times more potent than tramadol and two to three times less potent than morphine. It has no identified analgesically active metabolite and is not significantly metabolised by cytochrome P450 enzymes, thus overcoming some limitations of tramadol, including the potential for pharmacokinetic drug-drug interactions and interindividual variability due to genetic polymorphisms of cytochrome P450 enzymes. The toxicity profiles of tramadol and tapentadol are similar; however tapentadol is likely to result in less exposure to serotoninergic adverse effects (nausea, vomiting, hypoglycaemia) but cause more opioid adverse effects (constipation, respiratory depression, abuse) than tramadol. The safety of tapentadol in real-world conditions remains poorly documented, particularly in at-risk patient subgroups and also in the ability to assess the risk associated with its residual serotonergic activity (serotonin syndrome, seizures). Because of an earlier market introduction, more real-world safety data are available for tramadol, including data from at-risk patient subgroups. The level of evidence on the efficacy of both tramadol and tapentadol for the treatment of chronic pain is globally low. The trials published to date show overall that tapentadol does not provide a clinically significant analgesic improvement compared to existing treatments, for which the safety profile is much better known. In conclusion, tapentadol is not a first-line opioid but represents an additional analgesic in the therapeutic choices, which some patients may benefit from after careful examination of their clinical situation, co-morbidities and co-medications.

https://fpm.ac.uk/opioids-aware-structu … ng-opioids

Bonjour,

Je suis exactement dans le même cas
Je suis sous fluoxetine depuis peu (anciennement sous escitalopram puis Zoloft) et aujourd’hui je change car j’ai pris trop de poids avec ce traitement.

J’espère que je pourrai réduire le tramadol jusqu’à arrêt …