[ Effets secondaires ]

Douleur intense sous LSD

Any compound that stimulates the sympathetic nervous division can cause vasoconstriction, if you are worried about these compounds affecting your CAD it might be wise to have access to some sublingual nitroglycerin if you feel some chest tightness or angina. Are you currently taking any calcium channel blockers or ACE inhibitors? It might also be worthwhile doing a quick check about drug interactions.

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The bulk of the vasocontriction produced by 5-ht2a stimulation is due to activation of calcium channels, and to a lesser extent, stimulation of the COX pathway (which produces vasoconstrictor substances). References below.

If you happen to be on a calcium channel blocker (CCB), this should offer some protection against the vasoconstriction produced by many psychedelics. Verapamil is my preference for this purpose. If you prefer the natural route, magnesium is a natural calcuim channel antangonist. Obviously, you'd want to be under the care of a physician before taking these kinds of meds.

Blocking the COX pathway is also beneficial in this setting. Typically, NSAIDs tend to slightly increase blood pressure (so using them for this purpose seems counterintuitive), but in the context of lots of 5-ht2a stimulation, the net benefit is a reduction in vasocontriction. Again, my preference for this is ibuprofen, which I take before/during every trip. In my experience, ibuprofen also reduces some of the other psychedelic side-effects, like increased mucous production. But there's a caveat. I've found that ibuprofen, if the dose is high enough, also alters the mental part of the trip. The trip becomes more lucid, and less trippy. This is not always a good thing - I like the crazy mindset sometimes. As to why COX inhibitors would alter the mental part of a trip, there's long been evidence that NSAIDs have a positive effect on various neurological diseases - it's been studied in schizophrenia and Alzheimer's disease, among others, so they are clearly active in the brain.

In any case, be cautious about using antihypertensive meds for tripping purposes. Typically, the effects of the blood pressure meds (nitroglycerin excluded) have a longer duration than the vasoconstrictive effects of psychedelics, which means you can get a large drop in blood pressure when the trip ends. I nearly killed myself by downing lots of blood pressure meds when I panicked during a trip, and when the trip ended, my blood pressure crashed dramatically.

References (I posted these on another website, btw, which also includes more info on this topic):

1). Contribution of thromboxane A2 in rat common carotid artery response to serotonin. Sci Pharm. 2010;73):435-43. doi: 10.3797/scipharm.1004-04. Epub 2010 Jun 15.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002812/

2). Endogenous vasoconstrictor prostanoids: role in serotonin and vasopressin-induced coronary vasoconstriction. J Pharmacol Exp Ther. 1991 Jul 1;251):292-8.

http://www.ncbi.nlm.nih.gov/pubmed/2072301

ce problème peut apparaitre sur tous les produits qui stimulent les récepteurs 5ht2a (récepteur sérotoninergique) ...c'est un problème courant.


éventuellement cela peut venir de la muscu? (magnésium ? a essayer c'est peu risqué) et peut être que ta pote a d'autres problèmes...l'effet placebo peut être très trompeur alors si tu lui as parlé du problème avant.

Aussi cela peut être dû a des traitements par exemple.. des interactions entre d'éventuels médocs et le produit que tu as pris. Siinon il est possible que ce soit une imitation plus VC que le lsd du genre un 2C-x. Genre si tu as un soucis à  ce niveau là , avec le LSA ou les nbome tu vas douiller et les 2Cx/phénéthylamines c'est pas évident!


cordialement
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