Cannabis Abstinence Is Associated With Improved Memory.

Cette étude démontre que les effets sur certaines fonction cognitives attribuées au cannabis sont réversible et très rapidement.
Des tests cognitifs réguliers ont permis de constater que la mémoire, en particulier la mémoire verbale, s'améliorait significativement après une semaine seulement d'arrêt du cannabis.

One Month of Cannabis Abstinence in Adolescents and Young Adults Is Associated With Improved Memory.

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J Clin Psychiatry. 2018 Oct 30;79(6). pii: 17m11977. doi: 10.4088/JCP.17m11977.
One Month of Cannabis Abstinence in Adolescents and Young Adults Is Associated With Improved Memory.
Schuster RM1,2, Gilman J2, Schoenfeld D3, Evenden J4, Hareli M2, Ulysse C3, Nip E2, Hanly A2,5, Zhang H3, Evins AE2.
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Abstract
OBJECTIVE:

Associations between adolescent cannabis use and poor neurocognitive functioning have been reported from cross-sectional studies that cannot determine causality. Prospective designs can assess whether extended cannabis abstinence has a beneficial effect on cognition.
METHODS:

Eighty-eight adolescents and young adults (aged 16-25 years) who used cannabis regularly were recruited from the community and a local high school between July 2015 and December 2016. Participants were randomly assigned to 4 weeks of cannabis abstinence, verified by decreasing 11-nor-9-carboxy-??-tetrahydrocannabinol urine concentration (MJ-Abst; n = 62), or a monitoring control condition with no abstinence requirement (MJ-Mon; n = 26). Attention and memory were assessed at baseline and weekly for 4 weeks with the Cambridge Neuropsychological Test Automated Battery.
RESULTS:

Among MJ-Abst participants, 55 (88.7%) met a priori criteria for biochemically confirmed 30-day continuous abstinence. There was an effect of abstinence on verbal memory (P = .002) that was consistent across 4 weeks of abstinence, with no time-by-abstinence interaction, and was driven by improved verbal learning in the first week of abstinence. MJ-Abst participants had better memory overall and at weeks 1, 2, 3 than MJ-Mon participants, and only MJ-Abst participants improved in memory from baseline to week 1. There was no effect of abstinence on attention: both groups improved similarly, consistent with a practice effect.
CONCLUSIONS:

This study suggests that cannabis abstinence is associated with improvements in verbal learning that appear to occur largely in the first week following last use. Future studies are needed to determine whether the improvement in cognition with abstinence is associated with improvement in academic and other functional outcomes.
TRIAL REGISTRATION:

ClinicalTrials.gov identifier: NCT03276221.

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Dernière modification par Mister No (12 décembre 2018 à  10:42)